Description
CD137/NF-κB Reporter - HEK293 Recombinant Cell Line | 79289 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Cell Line
Application: • Screen for activators or inhibitors of CD137 signaling in a cellular context • Characterize the biological activity of CD137 and its interactions with ligands
Background: Human CD137 (4-1BB; TNFRS9) is an inducible co-stimulatory molecule that activates T cells. CD137:CD137L-mediated signaling has been shown to be important for proliferation, effector functions and survivals of T cells. CD137 is also expressed in NK and NKT cells. Accumulating evidence shows a role for CD137:CD137L signaling in inflammation, suggesting that inhibition of this pathway may provide a therapeutic avenue to treat autoimmune and inflammatory diseases. Similarly, antibodies targeting CD137 activation in immune cells have demonstrated potent anti-tumor properties in cancer patients.
Description: Recombinant HEK293 cell line expressing a full length human CD137 (NM_003811). The NF-κB luciferase reporter construct is stably integrated into the genome. The firefly luciferase gene is controlled by 4 copies of NF-κB response element located upstream of the TATA promoter. Following activation by human CD137 ligand, NF-κB transcription factors bind to the DNA response elements to induce transcription of the luciferase gene.
Product Type: Cell Line
Shippement Condition: -80°C
