Description
CD137 Antibody / 4-1BB / TNFRSF9 | V8353-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: LOB12
Host Animal: Rat
Clonality: Monoclonal (rat origin)
Species Reactivity: Mouse
Application: Functional Studies, FACS, IF
Buffer: N/A
Limitation: This CD137 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivowhen administered in combination with immune checkpoint inhibitors.
Immunogen: A murine CD137 human Fc fusion protein was used as the immunogen for the CD137 antibody.
Storage: Store the CD137 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
