Description
CBL-B TR-FRET Assay Kit | 79575 | Gentaur US, UK & Europe Disrtribition
Category: Ubiquitination/Ligases (E3)
Application: Great for screening small molecular inhibitors for drug discovery and HTS applications.
Background: N/A
Description: Human Casitas B-lineage lymphoma proto-oncogene b (CBL-B) is an E3 ubiquitinprotein ligase that functions as a negative regulator of T-cell activation. It is a promising drug target in cancer immunotherapy. The CBL-B TR-FRET Assay Kit is designed to measure CBL-B auto-ubiquitination activity in a homogeneous 384 reaction format. It utilizes biotin-labeled Ubiquitin and a terbium-labeled anti-CBL-B antibody to complete the TR-FRET pairing. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications.
Product Type: Assay Kit
Shippement Condition: -80°C