Description
Caspase-3 Antibody | F50514-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS pH 7.4 with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, FACS, IHC, ELISA
Buffer: N/A
Limitation: This anti-Caspase-3 antibody is available for research use only.
Purity: Purified
Description: CASP3 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Immunogen: A portion of amino acids 60-90 from the human protein was used as the immunogen for this anti-Caspase-3 antibody.
Storage: Aliquot the anti-Caspase-3 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
