Description
Canine IL-2 R alpha / CD25 Protein, His Tag | ILA-C52H4-1mg| Gentaur Distribution US, UK & Europe
Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.
Source: Canine IL-2 R alpha, His Tag (ILA-C52H4) is expressed from human 293 cells (HEK293). It contains AA Asp 22 - Gln 237 (Accession # O62802-1).
Format: Powder.
Tag: C-10×His.
Expression System: HEK293.
Expression Region: Asp 22 - Gln 237.
Conjugate: Unconjugated.
Molecular Weight: 26.4 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.4 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
