Canine B7-H4 Protein, His Tag (MALS verified) | B74-C52H8-1mg

Canine B7-H4 Protein, His Tag (MALS verified) | B74-C52H8-1mg| Gentaur Distribution US, UK & Europe

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

Source: Canine B7-H4, His Tag (B74-C52H8) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Ala 258 (Accession # XP_038547815.1).

Format: Powder.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Phe 29 - Ala 258.

Conjugate: Unconjugated.

Molecular Weight: 27.2 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.2 kDa. The protein migrates as 44-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT