Cadherin 16 Antibody | V7648SAF-100UG

Cadherin 16 Antibody | V7648SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: CDH16/2448

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: ELISA, IHC-P

Buffer: N/A

Limitation: This CDH16 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin (also called CDH16 and Cadherin 16). Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

Immunogen: A recombinant human partial protein (amino acids 371-507) was used as the immunogen for the CDH16 antibody.

Storage: Store the CDH16 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).