c-Mer, GST-tag | 40254

c-Mer, GST-tag | 40254 | Gentaur US, UK & Europe Disrtribition

Category: Kinase/Receptor Tyrosine

Application: Useful for the study of enzyme kinetics and for inhibitor screening.

Background: c-MER is a tyrosine kinase and a member of the MER/AXL/TYRO3 receptor kinase family (1). The c-MER gene encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. Functional knockout of c-MER in mice shows the mice to have macrophages deficient in the clearance of apoptotic thymocytes thereby demonstrating the critical role for c-MER in the engulfment and efficient clearance of apoptotic cells. Defects in c-MER have been associated with retinitis pigmentosa, a phenotype that can be reversed by replacement of the c-MER gene product (2).

Description: Human c-Mer, also known as tyrosine-protein kinase Mer, MERTK, and receptor tyrosine kinase MerTK GenBank Accession NM_006343, a.a. 578-872 with Cterminal GST-tag. Expressed in a baculovirus-infected Sf9 cell expression system. MW = 60 kDa.

Product Type: Protein

Shippement Condition: -80°C