c-Fos Monoclonal Antibody | E-AB-22158

c-Fos Monoclonal Antibody | E-AB-22158 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse, Rat

Host: Mouse

Isotype: IgG

Application: WB, IHC-p

Research Area: Cancer, Epigenetics and Nuclear Signaling, Neuroscience

Background: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Protein

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Purification: Protein A purification

Dilution: WB 1:500-1:2000, IHC 1:100-1:300 ELISA 1:40000

Conjugation: Unconjugated

Calculated Molecular Weight: N/A

Observed Molecular Weight: 62 kDa

Clonality: Monoclonal