Description
c-Fos Antibody | R30378 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat
Application: WB
Buffer: N/A
Limitation: This c-Fos antibody is available for research use only.
Purity: Antigen affinity
Description: The human oncogene c-Fos is the cellular homolog of the transforming gene of Finkel-Biskis-Jinkins(FBJ) murine osteosarcoma virus which was mapped to a single human chromosome. The protein is encoded by the FOS gene. It was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family. c-Fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth, differentiation, and transformation. Using transgenic and knockout mice, Grigoriadis et al.(1995) established a unique role for the proto-oncogene and nuclear transcription factor in regulating the differentiation and activity of specific bone cell populations, both during normal development and in bone disease.
Immunogen: Amino acids 170-187 (DQLEDEKSALQTEIANLL) were used as the immunogen for this c-Fos antibody (100% homologous in human, mouse and rat).
Storage: After reconstitution, the c-Fos antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
