BTLA Antibody / CD272 | V7708-20UG

BTLA Antibody / CD272 | V7708-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: BTLA/1528

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: ELISA

Buffer: N/A

Limitation: This BTLA antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: B and T lymphocyte attenuator (BTLA) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T-cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are coinhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T-cell activation by propagating inhibitory signals through BTLA. The BTLAHVEM interaction is conserved between Mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation.

Immunogen: Recombinant extracellular human CD272/BTLA protein was used as the immunogen for this BTLA antibody.

Storage: Store the BTLA antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).