Description
BTLA Antibody / CD272 | V7708-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: BTLA/1528
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: ELISA
Buffer: N/A
Limitation: This BTLA antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: B and T lymphocyte attenuator (BTLA) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T-cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are coinhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T-cell activation by propagating inhibitory signals through BTLA. The BTLAHVEM interaction is conserved between Mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation.
Immunogen: Recombinant extracellular human CD272/BTLA protein was used as the immunogen for this BTLA antibody.
Storage: Store the BTLA antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
