BTK Antibody | F50702-0.4ML

BTK Antibody | F50702-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, IF, IHC, ELISA

Buffer: N/A

Limitation: This BTK antibody is available for research use only.

Purity: Purified

Description: BTK plays a crucial role in B-cell ontogeny. This protein transiently phosphorylates GTF2I on tyrosine residues in response to B-cell receptor cross-linking. Defects in BTK are the cause of X-linked agammaglobulinemia type 1 (XLA). XLA is a humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes. This results in a lack of immunoglobulins of all classes and leads to recurrent bacterial infections like otitis, conjunctivitis, dermatitis, sinusitis or fatal sepsis or meningitis within the first years of life.

Immunogen: A portion of amino acids 209-239 from the human protein was used as the immunogen for this BTK antibody.

Storage: Aliquot the BTK antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.