Biotinylated SARS-CoV-2 Spike S2 protein, His, Avitag™ (BA.2/Omicron) | S2N-C82E4-25ug

Biotinylated SARS-CoV-2 Spike S2 protein, His, Avitag™ (BA.2/Omicron) | S2N-C82E4-25ug| Gentaur Distribution US, UK & Europe

It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Source: Biotinylated SARS-CoV-2 Spike S2 protein, His, Avitag™ (BA.2/Omicron) (S2N-C82E4) is expressed from human 293 cells (HEK293). It contains AA Ser 686 - Pro 1213 (Accession # QHD43416.1 (N764K, D796Y, Q954H, N969K, F817P, A892P, A899P, A942P, K986P, V987P) ). The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BA.2/3/4/5). Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) are introduced to prevent the formation of aggregates in the course of protein production.

Format: Powder.

Tag: C-10×His & C-Avi.

Expression System: HEK293.

Expression Region: Ser 686 - Pro 1213.

Conjugate: Biotin-labeled.

Molecular Weight: 61.7 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 61.7 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT