Biotinylated SARS-CoV-2 S protein RBD (K417T, E484K, N501Y), His, Avitag™ | SPD-C82E7-200ug

Biotinylated SARS-CoV-2 S protein RBD (K417T, E484K, N501Y), His, Avitag™ | SPD-C82E7-200ug| Gentaur Distribution US, UK & Europe

It's been reported that coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Source: Biotinylated SARS-CoV-2 S protein RBD (K417T, E484K, N501Y), His, Avitag (SPD-C82E7) is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537 (Accession # QHD43416.1 (K417T, E484K, N501Y) ). K417T/ E484K/ N501Y mutations were identified in the SARS-CoV-2 Gamma variant (Pango lineage: P.1; other names: 20J/501Y.V3).

Format: Powder.

Tag: C-10×His & C-Avi.

Expression System: HEK293.

Expression Region: Arg 319 - Lys 537.

Conjugate: Biotin-labeled.

Molecular Weight: 28.2 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 28.2 kDa. The protein migrates as 33-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT