Biotinylated Mouse Osteopontin (OPN) Protein, His, Avitag™ (MALS verified) | OPN-M82E8-25ug

Biotinylated Mouse Osteopontin (OPN) Protein, His, Avitag™ (MALS verified) | OPN-M82E8-25ug| Gentaur Distribution US, UK & Europe

Osteopontin (OPN) is also known as Secreted phosphoprotein 1 (SPP1), Bone sialoprotein 1, Nephropontin, Urinary stone protein, Uropontin, BNSP, which belongs to the osteopontin family. OPN / SPP1 is a highly negatively charged, extracellular matrix protein that lacks an extensive secondary structure. Full length OPN (OPN-FL) can be modified by thrombin cleavage, which exposes a cryptic sequence, SVVYGLR on the cleaved form of the protein known as OPN-R. Osteopontin / SPP-1 is biosynthesized by a variety of tissue types. OPN is the ligand for integrin alpha-V/beta-3. OPN / SPP1 binds tightly to hydroxyapatite and appears to form an integral part of the mineralized matrix. OPN / SPP1 probably important to cell-matrix interaction. OPN / SPP1 acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Source: Biotinylated Mouse Osteopontin, His, Avitag (OPN-M82E8) is expressed from human 293 cells (HEK293). It contains AA Leu 17 - Asn 294 (Accession # Q547B5-1).

Format: Powder.

Tag: C-10×His & C-Avi.

Expression System: HEK293.

Expression Region: Leu 17 - Asn 294.

Conjugate: Biotin-labeled.

Molecular Weight: 34.3 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 34.3 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, 0.2 M Arginine, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT