Description
Biotinylated Mouse IL-31 Protein, His, Avitag™ (MALS verified) | IL1-M82Q9-25ug| Gentaur Distribution US, UK & Europe
IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.
Source: Biotinylated Mouse IL-31, His, Avitag (IL1-M82Q9) is expressed from human 293 cells (HEK293). It contains AA Thr 24 - Cys 163 (Accession # Q6EAL8-1).
Format: Powder.
Tag: N-10×His & N-Avi.
Expression System: HEK293.
Expression Region: Thr 24 - Cys 163.
Conjugate: Biotin-labeled.
Molecular Weight: 19.2 kDa.
Characteristics: This protein carries a polyhistidine tag at the N-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 19.2 kDa. The protein migrates as 20-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
