Biotinylated Human Siglec-15 / CD33L3 Protein, His, Avitag™ (recommended for biopanning) | SG5-H82E9-25ug

Biotinylated Human Siglec-15 / CD33L3 Protein, His, Avitag™ (recommended for biopanning) | SG5-H82E9-25ug| Gentaur Distribution US, UK & Europe

Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig) -like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Source: Biotinylated Human Siglec-15 Protein, His, Avitag (SG5-H82E9) is expressed from human 293 cells (HEK293). It contains AA Phe 20 - Thr 263 (Accession # Q6ZMC9-1).

Format: Powder.

Tag: C-10×His & C-Avi.

Expression System: HEK293.

Expression Region: Phe 20 - Thr 263.

Conjugate: Biotin-labeled.

Molecular Weight: 30.1 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 30.1 kDa. The protein migrates as 33-43 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: 25 mM MES, 150 mM NaCl, pH5.5.

Storage Conditions: -20℃.

Shipping Conditions: RT