Description
Biotinylated Human Siglec-15 / CD33L3 Protein, His, Avitag™ (recommended for biopanning) | SG5-H82E9-200ug| Gentaur Distribution US, UK & Europe
Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig) -like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.
Source: Biotinylated Human Siglec-15 Protein, His, Avitag (SG5-H82E9) is expressed from human 293 cells (HEK293). It contains AA Phe 20 - Thr 263 (Accession # Q6ZMC9-1).
Format: Powder.
Tag: C-10×His & C-Avi.
Expression System: HEK293.
Expression Region: Phe 20 - Thr 263.
Conjugate: Biotin-labeled.
Molecular Weight: 30.1 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 30.1 kDa. The protein migrates as 33-43 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: 25 mM MES, 150 mM NaCl, pH5.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
