Biotinylated Human PD-L2 / B7-DC Protein, Fc, Avitag™ (MALS verified) | PD2-H82F6-25ug

Biotinylated Human PD-L2 / B7-DC Protein, Fc, Avitag™ (MALS verified) | PD2-H82F6-25ug| Gentaur Distribution US, UK & Europe

Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Source: Biotinylated Human PD-L2, Fc, Avitag (PD2-H82F6) is expressed from human 293 cells (HEK293). It contains AA Leu 20 - Pro 219 (Accession # Q9BQ51-1).

Format: Powder.

Tag: C-Fc & C-Avi.

Expression System: HEK293.

Expression Region: Leu 20 - Pro 219.

Conjugate: Biotin-labeled.

Molecular Weight: 51.0 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 51.0 kDa. The protein migrates as 66-91 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: Tris with Glycine,  Arginine and NaCl,  pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT