Description
Biotinylated Human Mucin-1 (890-1158) Protein, His, Avitag™ | MU1-H82E5-25ug| Gentaur Distribution US, UK & Europe
Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.
Source: Biotinylated Human Mucin-1 (890-1158), His, Avitag (MU1-H82E5) is expressed from human 293 cells (HEK293). It contains AA Ser 890 - Gly 1158 (Accession # P15941-1).
Format: Powder.
Tag: C-10×His & C-Avi.
Expression System: HEK293.
Expression Region: Ser 890 - Gly 1158.
Conjugate: Biotin-labeled.
Molecular Weight: 21.3 kDa (partial α chain) & 10.2 kDa (partial β chain).
Characteristics: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The mature form of Mucin-1 is a non-covalent heterodimeric complex with the proteolytically cleaved partial α and partial β chain. Each partial α and partial β chain has a calculated MW of 21.3 kDa (partial α chain) and 10.2 kDa (partial β chain). The protein migrates as 45-70 kDa (partial α chain) and 7 kDa and 14-15 kDa (partial β chain) under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
