Description
Biotinylated Human MR1&B2M Complex Protein (MALS verified) | MRM-H82W5-200ug| Gentaur Distribution US, UK & Europe
MR1 is also knwon as MHC class I-related gene protein. Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1-2 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers. Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5- (2-oxoethylideneamino) -6-D-ribitylaminouracil (5-OE-RU) and 5- (2-oxopropylideneamino) -6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively.
Source: Biotinylated Human MR1&B2M Complex Protein (MRM-H82W5) is expressed from human 293 cells (HEK293). It contains AA Arg 23 - Met 302 (Accession # Q95460-1 (MR1) & P61769-1 (B2M) ).
Format: Powder.
Tag: C-10×His & C-Avi.
Expression System: HEK293.
Expression Region: Arg 23 - Met 302.
Conjugate: Biotin-labeled.
Molecular Weight: 36.3 kDa and 11.7 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 36.3 kDa and 11.7 kDa. The protein migrates as 42-45 kDa and 13 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
