Description
Biotinylated Human Mesothelin-like protein / MSLNL, His, Avitag™ | MEN-H52E7-200ug| Gentaur Distribution US, UK & Europe
Loss of gene function is implicated in the emergence of novel phenotypes during organism evolution. Human MSLNL has a nonsense mutation in exon 10 and two polymorphic mutations: a frameshift in exon 3 and a nonsense codon in exon 8. The gorilla gene also shows multiple deleterious mutations, including a premature stop codon, a deletion, and a splice site mutation. Molecular evolutionary analysis indicated relaxed selection pressure on MSLNL in African great ape lineages, which suggested that MSLNL might have become inactivated before the divergence of human, chimpanzee and gorilla. The mouse Mslnl gene is highly expressed in olfactory epithelium and moderately expressed in several other tissues. We propose that the loss of MSLNL may be associated with the evolution of the olfactory system in African great apes including human.
Source: Biotinylated Human Mesothelin-like protein, His, Avitag (MEN-H52E7) is expressed from human 293 cells (HEK293). It contains AA Lys 36 - Trp 638 (Accession # Q96KJ4-1).
Format: Powder.
Tag: C-10×His & C-Avi.
Expression System: HEK293.
Expression Region: Lys 36 - Trp 638.
Conjugate: Biotin-labeled.
Molecular Weight: 68.5 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 68.5 kDa. The protein migrates as 95-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
