Description
Biotinylated Human Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein, His, Avitag™&Tag Free | IT1-H82W6-25ug| Gentaur Distribution US, UK & Europe
Integrin alpha-5/beta-1 is a receptor for ibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-V/beta-1 is also a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.
Source: Biotinylated Human ITGAV&ITGB1 Heterodimer Protein, His, Avitag&Tag Free (IT1-H82W6) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) & Gln 21 - Asp 728 (ITGB1) (Accession # NP_002201.1 (ITGAV) & NP_002202.2 (ITGB1) ).
Format: Powder.
Tag: C-10×His & C-Avi | Native.
Expression System: HEK293.
Expression Region: Phe 31 - Val 992 (ITGAV) & Gln 21 - Asp 728 (ITGB1).
Conjugate: Biotin-labeled.
Molecular Weight: 114.7 kDa (ITGAV) & 83.7 kDa (ITGB1).
Characteristics: Biotinylated Human ITGAV&ITGB1 Heterodimer Protein, His, Avitag&Tag Free, produced by co-expression of ITGAV and ITGB1, has a calculated MW of 114.7 kDa (ITGAV) and 83.7 kDa (ITGB1). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag (Avitag™) and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 135-150 kDa (ITGAV) and 100-115 kDa (ITGB1) respectively due to glycosylation.
Purity: 95%.
Buffer: 50 mM Tris, 150 mM NaCl, pH 7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
