Biotinylated Human HLA-A*02:01&B2M&p53 (HMTEVVRRC) Complex Protein (Monomer, MALS verified) | HLP-H82E4-200ug

Biotinylated Human HLA-A*02:01&B2M&p53 (HMTEVVRRC) Complex Protein (Monomer, MALS verified) | HLP-H82E4-200ug| Gentaur Distribution US, UK & Europe

TP53 has been recognized as a tumor suppressor. 50% of cancers carry a TP53 mutation while many others affect other pathway components. High-copy numbers of WT p53 peptide-MHC class I complexes were detected on tumor cells as compared to low copies on normal cells. The Human HLA-A*0201 p53 (HMTEVVRRC) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M, and HMTEVVRRC peptide of the p53.

Source: Biotinylated Human HLA-A*02:01&B2M&p53 (HMTEVVRRC) Complex Protein (HLP-H82E4) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & HMTEVVRRC peptide (Accession # AAA59606.1 (HLA-A*02:01) & P61769-1 (B2M) & HMTEVVRRC).

Format: Liquid.

Tag: C-10×His & C-Avi.

Expression System: HEK293.

Expression Region: Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & HMTEVVRRC peptide.

Conjugate: Biotin-labeled.

Molecular Weight: 36.3 kDa and 11.7 kDa.

Characteristics: Biotinylated Human HLA-A*02:01&B2M&p53 (HMTEVVRRC) Complex Protein is produced by co-expression of HLA and B2M loaded with p53 peptide. This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 36.3 kDa and 11.7 kDa. The protein migrates as 38-43 kDa and 12 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -70℃.

Shipping Conditions: Dry ice