Description
Biotinylated Human GUCY2C / Guanylyl cyclase C Protein, Fc, Avitag™ | GUC-H82F8-200ug| Gentaur Distribution US, UK & Europe
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
Source: Biotinylated Human GUCY2C, Fc, Avitag (GUC-H82F8) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Gln 430 (Accession # P25092-1).
Format: Powder.
Tag: C-Fc & C-Avi.
Expression System: HEK293.
Expression Region: Ser 24 - Gln 430.
Conjugate: Biotin-labeled.
Molecular Weight: 74.1 kDa.
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 74.1 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
