Biotinylated Human GITR Ligand / TNFSF18 Protein, Avitag™, Fc Tag | GIL-H82F8-200ug

Biotinylated Human GITR Ligand / TNFSF18 Protein, Avitag™, Fc Tag | GIL-H82F8-200ug| Gentaur Distribution US, UK & Europe

Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.

Source: Biotinylated Human GITR Ligand, Avitag, Fc Tag (GIL-H82F8) is expressed from human 293 cells (HEK293). It contains AA Gln 50 - Ser 177 (Accession # AAH69319.1).

Format: Powder.

Tag: N-Avi & N-Fc.

Expression System: HEK293.

Expression Region: Gln 50 - Ser 177.

Conjugate: Biotin-labeled.

Molecular Weight: 43.5 kDa.

Characteristics: This protein carries an Avi tag (Avitag™) at the N-terminus, followed by a human IgG1 Fc tag. The protein has a calculated MW of 43.5 kDa. The protein migrates as 45-53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: Tris with Glycine,  Arginine and NaCl,  pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT