Biotinylated Human Complement C3a Protein, His, Avitag™ | COA-H82Q3-25ug

Biotinylated Human Complement C3a Protein, His, Avitag™ | COA-H82Q3-25ug| Gentaur Distribution US, UK & Europe

C3 is the major complement component serum. It is mainly synthesized by macrophages and liver. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. It is cleaved into two fragments, C3a and C3b. C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Source: Biotinylated Human Complement C3a Protein, His, Avitag (COA-H82Q3) is expressed from human 293 cells (HEK293). It contains AA Ser 672 - Arg 748 (Accession # P01024).

Format: Powder.

Tag: N-10×His & N-Avi.

Expression System: HEK293.

Expression Region: Ser 672 - Arg 748.

Conjugate: Biotin-labeled.

Molecular Weight: 12.7 kDa.

Characteristics: This protein carries a polyhistidine tag at the N-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 12.7 kDa. The protein migrates as 13-16 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT