Description
Biotinylated Human CLEC12A / MICL / CLL-1 Protein, His, Avitag™ | CLA-H82E6-25ug| Gentaur Distribution US, UK & Europe
CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.
Source: Biotinylated Human CLEC12A, His, Avitag (CLA-H82E6) is expressed from human 293 cells (HEK293). It contains AA His 65 - Ala 265 (Accession # Q5QGZ9-2).
Format: Powder.
Tag: N-Avi & N-10×His.
Expression System: HEK293.
Expression Region: His 65 - Ala 265.
Conjugate: Biotin-labeled.
Molecular Weight: 27.3 kDa.
Characteristics: This protein carries an Avi tag (Avitag™) at the N-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 27.3 kDa. The protein migrates as 35-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
