Description
Biotinylated Human Alpha-Synuclein Protein, His, Avitag™ | ALN-H82H8-200ug| Gentaur Distribution US, UK & Europe
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
Source: Biotinylated Human Alpha-Synuclein, His, Avitag (ALN-H82H8) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1).
Format: Powder.
Tag: C-10×His & C-Avi.
Expression System: E. coli.
Expression Region: Met 1 - Ala 140.
Conjugate: Biotin-labeled.
Molecular Weight: 18.0 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 18.0 kDa. The protein migrates as 23 kDa under reducing (R) condition (SDS-PAGE).
Purity: 95%.
Buffer: 100 mM NaAC, pH7.0.
Storage Conditions: -20℃.
Shipping Conditions: RT
