Description
Biotinylated Cynomolgus Siglec-10 Protein, His, Avitag™ (MALS verified) | SI0-C82E5-25ug| Gentaur Distribution US, UK & Europe
The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
Source: Biotinylated Cynomolgus Siglec-10 Protein, His, Avitag (SI0-C82E5) is expressed from human 293 cells (HEK293). It contains AA Thr 17 - Ala 549 (Accession # XP_005590164.1).
Format: Powder.
Tag: C-10×His & C-Avi.
Expression System: HEK293.
Expression Region: Thr 17 - Ala 549.
Conjugate: Biotin-labeled.
Molecular Weight: 62.0 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 62.0 kDa. The protein migrates as 80-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: 50 mM MES, 150 mM NaCl, 0.5 M Arginine, pH5.0.
Storage Conditions: -20℃.
Shipping Conditions: RT
