Biotinylated Bovine FcRn / FCGRT&B2M Heterodimer Protein, His, Avitag™ (MALS & SPR verified) | FCN-B82W3-25ug

Biotinylated Bovine FcRn / FCGRT&B2M Heterodimer Protein, His, Avitag™ (MALS & SPR verified) | FCN-B82W3-25ug| Gentaur Distribution US, UK & Europe

FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.

Source: MABSol® Biotinylated Bovine FcRn Heterodimer Protein, His, Avitag (FCN-B82W3) is expressed from human HEK293 cells. It contains AA Ala 24 - Pro 298 (FCGRT) & Ile 21 - Leu 118 (B2M) (Accession # Q3T119-1 (FCGRT) & P01888-1 (B2M) ).

Format: Powder.

Tag: C-10×His & C-Avi | Native.

Expression System: HEK293.

Expression Region: Ala 24 - Pro 298 (FCGRT) & Ile 21 - Leu 118 (B2M).

Conjugate: Biotin-labeled.

Molecular Weight: 34.5 kDa (FCGRT) and 11.6 kDa (B2M).

Characteristics: Biotinylated Bovine FcRn Heterodimer Protein, His, Avitag, produced by co-expression of FCGRT and B2M, has a calculated MW of 34.5 kDa (FCGRT) and 11.6 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™) and subunit B2M contains no tag. The reducing (R) protein migrates as 35-38 kDa (FCGRT) and 12 kDa (B2M) respectively due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT