Description
Biotin Anti-Mouse CD274/PD-L1 Antibody | DL21656F-2 | Gentaur US, UK & Europe Disrtribition
Synonyms: B7-H1, PD-L1, Programmed cell death ligand 1, B7 homolog 1, B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
Reactivity: Mouse
Host: Rat
Application: FCM
Background: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
Concentration: 0.5 mg/mL
Conjugation: Biotin
Buffer: PBS with 0.05% Proclin300, 1% BSA
Isotype: Rat IgG2b, κ
Storage: Store at 2~8°C. Do not freeze.
