Description
Beta Catenin Antibody | F54475-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: IF, FACS, IHC-P, WB
Buffer: N/A
Limitation: This Catenin Beta antibody is available for research use only.
Purity: Antigen affinity purified
Description: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Immunogen: A portion of amino acids 78-106 from the human protein was used as the immunogen for the Catenin Beta antibody.
Storage: Aliquot the Catenin Beta antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
