Description
Beta Arrestin 1 Antibody | F54014-0.1ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Format: Purified
Clone: 6A1-D7-C9
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: WB
Buffer: N/A
Limitation: This Beta Arrestin 1 antibody is available for research use only.
Purity: Protein G affinity
Description: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. [UniProt]
Immunogen: A human recombinant protein was used as the immunogen for this Beta Arrestin 1 antibody.
Storage: Store the Beta Arrestin 1 antibody at -20 °C.
