Beta Arrestin 1 Antibody / ARRB1 | F54630-0.4ML

Beta Arrestin 1 Antibody / ARRB1 | F54630-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: FACS, IF, IHC-P, WB

Buffer: N/A

Limitation: This ARRB1 antibody is available for research use only.

Purity: Antigen affinity purified

Description: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.

Immunogen: A portion of amino acids 336-363 from the human protein was used as the immunogen for the ARRB1 antibody.

Storage: Aliquot the ARRB1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.