Description
Beta-2 Microglobulin Antibody | V2803SAF-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free
Format: Purified
Clone: C21.48A1
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: FACS, WB, IF
Buffer: N/A
Limitation: This Beta-2 Microglobulin antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: The antibody recognizes the hidden determinant of beta-2 microglobulin (i.e. binding to its determinant is available only when the chain is separated from the HLA heavy chain). Beta-2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta-2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. Beta-2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).
Immunogen: Soluble beta 2 microglobulin was used as the immunogen for the Beta-2 Microglobulin antibody.
Storage: Store the Beta-2 Microglobulin antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
