Bcl10 Antibody | F54557-0.08ML

Bcl10 Antibody | F54557-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: FACS, IF, IHC-P, WB

Buffer: N/A

Limitation: This BCL10 antibody is available for research use only.

Purity: Antigen affinity purified

Description: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Immunogen: A portion of amino acids 24-51 from the human protein was used as the immunogen for the BCL10 antibody.

Storage: Aliquot the BCL10 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.