Description
BCL-2, His-tag | 50272 | Gentaur US, UK & Europe Disrtribition
Category: Apoptosis/Protein
Application: Useful for the study of apoptosis, screening inhibitors, and selectivity profiling.
Background: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Description: Human Bcl-2 (GenBank Accession No. P10415), a.a. 1-211 with C-terminal His-tag, MW = 27 kDa, expressed in an E. coli expression system.
Product Type: Protein
Shippement Condition: -80°C
