BAP1 Antibody / BRCA1-Associated Protein 1 | V8927-20UG

BAP1 Antibody / BRCA1-Associated Protein 1 | V8927-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: BAP1/6861R

Host: Rabbit

Clonality: Recombinant Rabbit Monoclonal

Isotype: Rabbit IgG, kappa

Species Reactivity: Human

Application: IHC-P

Application Details: Immunohistochemistry (FFPE): 1-2ug/ml

Application Note: Optimal dilution of the recombinant BAP1 antibody should be determined by the researcher.

Purity: Protein A/G affinity

Description: The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.

Immunogen: A portion of amino acids 400-729 was used as the immunogen for the recombinant BAP1 antibody.

Storage: Aliquot the recombinant BAP1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.

Localization: Nuclear, Cytoplasm