Description
BAFF-R - CHO K1 Recombinant Cell Line (Medium Expression) | 79921-M | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Cell Line
Application: • Screen for activators or inhibitors of antibody-mediated signaling for immunotherapy research and drug discovery.
• Characterize BAFF-R antibodies and ligands for binding assays.
Background: BAFF Receptor (B-cell activating factor receptor, BAFF-R) is an essential factor for B cell maturation and survival. In humans it is encoded by the TNFRSF13C gene. BAFF-R function is impressively documented in humans by a homozygous deletion, which leads to an almost complete block of B cell development at the stage of immature/transitional B cells. The resulting immunodeficiency is characterized by B-lymphopenia, agammaglobulinemia, and impaired humoral immune responses.
Description: Recombinant human BAFF-R-CHO K1 cell line stably expressing full length human BAFF-R/TNFRSF13C receptor (GenBank Accession: NM_052945.3). Surface expression of BAFF-R was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of BAFF-R expression (High, Medium, Low) to mimic different stages of cancer target cells with various BAFF-R expression levels.
Product Type: Cell Line
Shippement Condition: -80°C
