B2M Knockout THP-1 Cell Line | 78389

B2M Knockout THP-1 Cell Line | 78389 | Gentaur US, UK & Europe Disrtribition

Category: CAR-T/Cell Line

Application: • Study the consequences of B2M knock-down • Study T cell activation, antigen presentation, and immune responses

Background: THP-1 cells are monocytes, derived from an acute monocytic leukemia patient. Beta-2-Microglobulin is a required component of Major Histocompatibility Complex (MHC) class 1 molecules, which present peptide fragments from within the cell to cytotoxic T cells as part of the adaptive immune system. B2M plays an essential role both in governing MHC class I molecule stability and in promoting antigen binding and presenting the antigen to CD3/TCR complex of CD8+ T cells.

Description: B2M (Beta-2-Microglobulin) has been genetically removed by CRISPR/Cas9 genome editing from THP-1 cells.

Product Type: Cell Line

Shippement Condition: -80°C