B2M Knockout Jurkat Cell Line | 78342

B2M Knockout Jurkat Cell Line | 78342 | Gentaur US, UK & Europe Disrtribition

Category: CAR-T/Cell Line

Application: • Study the consequences of B2M knock-down • Study T cell activation, antigen presentation, and immune responses.

Background: Beta-2-Microglobulin is a required component of Major Histocompatibility Complex (MHC) class 1 molecules, which present peptide fragments from within the cell to cytotoxic T cells as part of the adaptive immune system. The protein forms amyloid fibrils in some pathological conditions. A mutation in this gene drives hypercatabolic hypoproteinemia. B2M plays an essential role both in governing MHC class I molecule stability and in promoting antigen binding and presenting the antigen to CD3/TCR complex of CD8+ T cells.

Description: B2M (Beta-2-Microglobulin) has been genetically removed by CRISPR/Cas9 genome editing from Jurkat cells.

Product Type: Cell Line

Shippement Condition: -80°C