B-Raf(V600E) Kinase Assay Kit | 48688

B-Raf(V600E) Kinase Assay Kit | 48688 | Gentaur US, UK & Europe Disrtribition

Category: Kinase/Assay Kit

Application: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.

Background: N/A

Description: B-raf, after stimulation by activated RAS, phosphorylates MEK1 resulting in activation of the mitogen-activated protein (MAP) kinase cascade. Since the MAPK cascade has been shown to be a critical factor in melanoma development, it has been proposed that targeting B-raf could be a promising approach to combat melanoma. More importantly, 40-60% of melanomas display a mutation in BRAF, e.g. B-Raf(V600E), which leads to constitutive activation of the MAP kinase pathway. The B-Raf(V600E) Kinase Assay Kit is designed to measure B-Raf(V600E) kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. In addition, the B-Raf(V600E) Kinase Assay Kit includes wild type B-Raf enzyme as a positive control for researchers investigating B-Raf(V600E) specific inhibitors.

Product Type: Assay Kit

Shippement Condition: -80°C