Description
b-Catenin Antibody | R30313 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat
Application: WB, IHC-P, IHC-F, ICC
Buffer: N/A
Limitation: This b-Catenin antibody is available for research use only.
Purity: Antigen affinity
Description: Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as alpha-catenin, which can bind to beta-catenin and can also bind actin, and beta-catenin. b-Catenin binds the cytoplasmic domain of some cadherins as an adherens junction protein. In normal tissues, b-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, it is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution throughout the cytoplasm results in a diffuse cytoplasmic pattern. It plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy, HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer.
Immunogen: A synthetic peptide corresponding to the N-terminus of the human protein (MATQADLMELDMAMEPDRK) was used as the immunogen for this b-Catenin antibody (100% homologous in human, mouse and rat).
Storage: After reconstitution, the b-Catenin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
