b-AP15 (NSC-687852) | 27701-2

b-AP15 (NSC-687852) | 27701-2 | Gentaur US, UK & Europe Disrtribition

Category: Ubiquitination/Inhibitors / Activators

Application: Suitable for validation studies of the deubiquitinating activities of the 19S regulatory particle as a drug target, as well as cell-based and in vitro characterization UCH-L5 or USP14 activity.

Background: N/A

Description: Blocks 26S proteasome activity by inhibiting the ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) activities of the 19S regulatory subunit without affecting the catalytic activity of the 20S core subunit. b-AP15 displays several differences to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in four solid tumor models.

Product Type: Inhibitors/Activators

Shippement Condition: gel packs