Description
b-AP15 (NSC-687852) | 27701-1 | Gentaur US, UK & Europe Disrtribition
Category: Ubiquitination/Inhibitors / Activators
Application: Suitable for validation studies of the deubiquitinating activities of the 19S regulatory particle as a drug target, as well as cell-based and in vitro characterization UCH-L5 or USP14 activity.
Background: N/A
Description: Blocks 26S proteasome activity by inhibiting the ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) activities of the 19S regulatory subunit without affecting the catalytic activity of the 20S core subunit. b-AP15 displays several differences to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in four solid tumor models.
Product Type: Inhibitors/Activators
Shippement Condition: gel packs
