Description
AZD2461 | 27606-1 | Gentaur US, UK & Europe Disrtribition
Category: PARP/Inhibitors / Activators
Application: N/A
Background: Unlike treatment with AZD 2281 (Olaparib, Axon 1464), AZD 2461 succesfully circumvents drug resistance of Pgp-proficient tumors, and inactivation of p53-binding protein 1 (53BP1) as a causal factor in PARPi resistance.
Description: AZD2461 is a novel PARP inhibitor with low affinity for than Olaparib. AZD2641 is currently in Phase I clinical studies to treat solid tumors.
Product Type: Inhibitor
Shippement Condition: Room temp. (continental US) or gel packs
