AXIN2 Antibody | F49172-0.08ML

AXIN2 Antibody | F49172-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, IHC, FACS, ELISA

Buffer: N/A

Limitation: This AXIN2 antibody is available for research use only.

Purity: Antigen affinity

Description: The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Immunogen: A portion of amino acids 816-843 from the human protein was used as the immunogen for this AXIN2 antibody.

Storage: Aliquot the AXIN2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.