Axin-1 Antibody | F41872-0.08ML

Axin-1 Antibody | F41872-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, IHC, ELISA

Buffer: N/A

Limitation: This Axin-1 antibody is available for research use only.

Purity: Antigen affinity

Description: Axin-1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for the gene.

Immunogen: A portion of amino acids 710-738 from the human protein was used as the immunogen for this Axin-1 antibody.

Storage: Aliquot the Axin-1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.