AURORA C, GST-tag | 40178

AURORA C, GST-tag | 40178 | Gentaur US, UK & Europe Disrtribition

Category: Kinase-Serine/Threonine/Protein

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: Aurora C is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. Aurora C has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumors (1). Aurora C overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. Aurora C is an important regulator of both genomic integrity and cell cycle progression in cancer cells and is an attractive target for anticancer drug development (2).

Description: Recombinant human Aurora C, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.

Product Type: Protein

Shippement Condition: -80°C